Burn injury has been reported to be an important cause of morbidity and mortality in many countries. It leads to a loss of integrity of the skin, which protects us from water loss, temperature change, radiation, trauma and infection. The main sources of stem cells therapy for Skin Burn that might be used for repair and regeneration of injured skin tissue are embryonic stem cells (ESCs) and adult stem cells. GIOSTAR has the ability to differentiate Bone Marrow Stem Cells and Mesenchymal Stem cells into epidermal cells and fibroblasts in vitro, and can accelerate the skin wound repair.